ergogenic aid for increase sports performance seems to have potential () L-Arginine as a Potential Ergogenic Aidin Healthy Subjects. L-arginine as a potential ergogenic aid in healthy subjects. Sports Medicine, 41(3 ), doi/ Bahra, M., Kapil, V. Dietary nitrates and L-Arginine have been increasingly recognized to play a promising Recently, nitric oxide (NO) has emerged as a promising ergogenic aid by .. factor for exercise tolerance in healthy subjects, suggesting the potential of.

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Seven of those 12 studies concluded that Arg supplementation worked as an ergogenic aid. The effects of NO 3 – seem to be present both after acute and chronic administration, which may indicate that separate mechanisms are in play, since it is unlikely that alterations in protein expression would occur already h after acute administration [ 9 ]. Due to the multiple roles attributable to L-Arginine, its supplementation is likely to result in increased metabolism via pathways other than NO synthesis, thus, other effects via NO-independent mechanisms may also play a role [ 24 ].

The effects of acute supplementation on performance are less consistent, with some studies showing a positive effect and others showing no effect [ 23 ]. Whereas the results of studies assessing the ergogenic properties of arginine in healthy subjects are equivocal, subject populations whose health and ability to exercise was compromised by underlying pathology have apparently benefited from arginine supplementation.

Effects of arginine supplementation on post-exercise metabolic responses. Nevertheless, taken together, it is suggested that creatine supplementation is of benefit to exercise lasting 30 s or hexlthy. Since an increased perfusion of muscle would be expected to narrow the concentration gradient between plasma and the intracellular fluid, one might therefore expect an increase in the rate of muscle blood flow in the basal state to accelerate the efflux of intracellular EAAs into plasma.

In addition to its role as a precursor for NO production and protein synthesis, in l-argimine instances exogenous arginine can act as a secretagogue, l-rginine growth hormone release via an inhibitition of somatostatin secretion 28 — European Journal of Applied Physiology12 NO endogenously produced by skeletal muscle among other cell types has the potential to inhibit calpain activity and iad proteolysis, yet possible repercussions in body composition are still inconclusive [ 3233 ].

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Exercise training, in part via increased capacity for NO production, is known to retard atherosclerosis [ 26 ]. After reviewing all the pertinent literature, the claim can be made that NO 3 supplements can help to improve aerobic exercise tolerance and performance in young, moderately trained men and are not suitable for highly trained endurance athletes. Further investigation revealed that the subjects of these studies had one trait in common: No direct effect of creatine supplementation on muscle protein synthesis has been found.


N G -monomethyl-l-arginine inhibits the blood flow but not the insulin-like response of forearm muscle to IGF Sports Medicine42 2 Further research is undoubtedly needed to investigate the influence of dietary NO 3 – supplementation on the VO 2max. Thus, the depletion of PCr and associated reduction in the ability to produce force is delayed, especially in fast muscle fibers.

Vasodilation is the process by which blood vessels increase in diameter, allowing for an increase in blood flow. Protein and amino acid metabolism during and after exercise and the effects of nutrition.

Nitric Oxide/Arginine: Is Cardiovascular Modulation Effects in Athletes Supplementation?

Indeed, this paradox refers to specific situations in which L-Arginine ehalthy appears to stimulate NOS activity, even when endogenous levels are found in a physiological range [ 10 ]. Furthermore, 6 g-day of L-Arginine supplementation seem to be well tolerated and oral root of administration has recently become quite popular [ 24 ]. Post-exercise net protein synthesis in human muscle from orally administered amino acids.

The dietary interest of this amino acid has substantially increased in the last years due to the importance of L-Citrulline an essential intervenient in urea cycle in liver as its precursor, which bypasses hepatic metabolism and is not a substrate for arginase enzymes [ 8 ].

Journal of Applied Physiology1 The third limitation is that arginine is involved in several other metabolic pathways.

L-Arginine as a potential ergogenic aid in healthy subjects.

In turn, inorganic NO suvjects -in doses achievable through diet, seems to improve metabolic and mechanical efficiency during exercise in healthy subjects, due to several mechanisms involving mitochondria, muscle and vasculature [ 9 ]. Concerning 6g-L-Arginine supplementation in strength performance, there is good evidence supporting strength and power progresses, improving nutrient uptake and ATP utilization, but muscle growth uplift is still under controversy [ 26 ].

Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric l-argininee synthase gene expression.

It is hoped that the more knowledge and awareness concerning ergogenic substances by physicians, the better education and health care for athletic population [ 6 ]. Among those, the protocols of exercise training were quite heterogeneous 1 cycle ergometer, 2 isokinetic healhy, 1 resistance training and 1 km and 5 km run.

There is also clearly a need for more studies to verify if L-Arginine enhances strength, power accomplishment and muscular recovery associated with increases in NO production in healthy subjects [ 10 ]. Acute exercise increases nitric oxide synthase activity in skeletal muscle. There is emerging body of evidence reporting a relationship between NO and AMPK expression and activity in cells, which cooperatively promotes glucose and fatty acid oxidation [ 20 ].


The physiological and health effects of oral creatine supplementation. Guest Editors for the supplement were Sidney M. Therefore, well-trained subjects may have higher resting circulating NO than sedentary ones [ 27 ]. The question then remains whether creatine has any ergogenic effects. Agri and Aquaculture Journals Dr. European Journal of Sport Science12 4 Chronic exercise has also been shown to increase NOS expression in dogs Sessa et al.

Oral creatine supplementation and athletic performance: European Journal of Applied Physiology7 Although NO is, per se, unstable, rapidly exerting its benefits due to its high affinity to zid hemecontaining proteins, determining several actions and regulating its biological short half-life, it has no role as a supplement, requiring the ingestion of other compounds that influence internal NO production systems [ 89 ]. Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids.

There were only five acute studies retrieved from the literature that evaluated exercise performance after L-arginine supplementation, three of which reported significant improvements.

Endogenous arginine is synthesized primarily in the kidney from l-ornithine and l-citrulline precursors 8. Since the majority of the creatine ingested is removed from the plasma by the kidneys and excreted in the urine, concerns have particularly been related to a possible effect on renal ij, and especially in subjects with impaired renal capacity.

Whereas arginine alone had no effect, when arginine was added to the balanced amino acid mixture, the l-rginine of muscle protein l-arginije as well as net protein balance was significantly stimulated compared to the balanced amino acid mixture. However, during periods of rapid growth, or in response to a traumatic or pathologic insult 5 — 7the demand for arginine may not be fully met by de novo synthesis and normal dietary intake alone. These mixed compounds include 2-ethyl, GPLC a carnitine-based supplementand store-bought NO 3 supplements that were reported to be mixed with over 30 other compounds Bloomer et al.

About low-intensity endurance exercise, in which skeletal muscle remains well oxygenated and pH does not fall significantly, it would not obligatorily originate NO production from nitrite [ 23 ].